Transdermal drug delivery systems are emerging as an effective method of administering therapeutic products, including anti-HIV agents. Transdermal drug delivery generally refers to the topical application of agents to healthy intact skin either for localized treatment of tissues underlying the skin or for delivery to the systemic circulation. For transdermal products, the goal of dosage design is to maximize the flux of drug product through the skin into the systemic circulation and simultaneously minimize the retention and metabolism of the drug in the skin. Among the various types of transdermal drug delivery systems available for various ailments, including matrix, micro-reservoir, adhesive, and membrane-matrix hybrid, the most common formulation is the incorporation of the drug into the polymer matrix of the transdermal film. Transdermal drug delivery systems have several advantages over conventional delivery, such as improved MCE Company 917879-39-1 patient compliance during long-term therapy of chronic conditions, reduced undesired side-effects by avoidance of first-pass metabolism and bolus high drug concentrations, sustained drug delivery, maintenance of constant and prolonged drug concentrations in plasma, reduced inter-patient and intra-patient variability, and the opportunity to interrupt or terminate treatment when necessary. Though IQP-0410 has been shown to be a highly potent agent for the therapy of HIV-1 infection, pharmacokinetic studies indicate that IQP-0410 will be subjected to extensive first pass metabolism by the liver. This limits the effectiveness of IQP-0410 when delivered through conventional methods. The purpose of this study was to prepare a transdermal film 1345982-69-5 containing IQP-0410 and investigate the physicochemical characteristics, in vitro release profiles, and ex vivo transdermal permeation of IQP-0410 from these films, as well as to assess the efficacy and toxicity of IQP-0410 when delivered from a transdermal film. The transdermal films were formulated through a solvent evaporation method. As shown in Table 1, the various film formulations that were initially developed were composed of Ethyl cellulose, Hydroproyl methylcellulose, Di-nbutyl phthalate, and Propylene glycol. A target dose of 2 per film was defined based upon previously developed
