Stinal type tumors more frequently expressed PKCa protein than did diffuse type tumors. According to general concept of gastric carcinogenesis, intestinal type and diffuse type carcinomas appear to evolve through different pathways, involving different oncogenes and tumor suppressor genes [26]. Gene expression profiling studies have shown that diffuse type carcinoma exhibits an altered expression of genes related to cell-matrix interaction and extracellular-matrix components, whereas intestinal type carcinoma exhibits enhanced cell growth [27]. Thus we conduct that PKCa protein plays a role in gastric carcinogenesis, especially intestinal type carcinoma. We also found PKCa protein overexpression to be statistically correlated with tumor differentiation. Well to moderately-differentiated tumors more frequently expressed PKCa protein than did poorly-differentiated ones. The association between PKCa activity and tumor differentiation and/or MedChemExpress BI 10773 histological grading has been reported for various malignancies. In superficial bladder cancer, abnormally activated PKCa may play a role in tumor differentiation, and elevated PKCa activation correlates with higher histological grade [28]. PKCa is highly expressed in poorlydifferentiated hepatocellular carcinoma cell lines [11]. In melanomas, PKCa activation is typically associated with decreased differentiation [12]. PKCa expression is elevated in high-grade endometrial tumors [19]. In breast cancer, expression of PKCa correlates with high histological grade and proliferation rate [17]. By contrast, one study reported that ovarian carcinoma exhibited decreasing in PKCa expression with increasing histological grade [29]. We found PKCa protein overexpression to be associated with histological grade and tumor differentiation in gastric carcinoma. In addition, we found that PKCa-positive high-grade dysplastic glands, precursor lesions of intestinal type carcinoma, were frequently observed in intestinal type carcinomas with PKCa protein overexpression. The PKCa protein is thus thought to be involved in the early stage of gastric carcinogenesis. PKCa has been thought to play an important role in tumor progression. It has been implicated in several cancer-related processes, such as EAI045 web invasion and metastasis [10]. The role of PKCa in regulating tumor growth and development 23727046 is clearly complex and highly tissue-dependent. In some cases PKCa acts as a tumor promoter, and in others it functions as a tumor suppressor [13]. In current immunohistochemical study, expression of PKCa protein was negatively statistically correlated to depth of invasion, angiolymphatic invasion, pathologic stage, and distant metastasis. We thus conduct that PKCa protein acts as a tumor suppressor, and downregulates gastric carcinoma progression. PKCa has been reported to be a prognostic marker in human cancers. In Kong’s study, high level PKCa predicted a shortened recurrence-free survival in patients with superficial bladder carcinomas [28]. Haughian et al demonstrated that PKCa level may be a prognostic indicator of aggressive endometrial cancers [19]. Patients with higher PKCa mRNA expression in hepatocellular carcinomas have a significantly decreased survival rate [21]. For patients 
with breast cancer, the prognostic significance of PKCa is controversial. L ne et al reported that patients with PKCa-positive breast carcinoma had a poorer survival rate [17], but Kerfoot et al found that PKCa was downregulated in advanced breast carcinoma.Stinal type tumors more frequently expressed PKCa protein than did diffuse type tumors. According to general concept of gastric carcinogenesis, intestinal type and diffuse type carcinomas appear to evolve through different pathways, involving different oncogenes and tumor suppressor genes [26]. Gene expression profiling studies have shown that diffuse type carcinoma exhibits an altered expression of genes related to cell-matrix interaction and extracellular-matrix components, whereas intestinal type carcinoma exhibits enhanced cell growth [27]. Thus we conduct that PKCa protein plays a role in gastric carcinogenesis, especially intestinal type carcinoma. We also found PKCa protein overexpression to be statistically correlated with tumor differentiation. Well to moderately-differentiated tumors more frequently expressed PKCa protein than did poorly-differentiated ones. The association between PKCa activity and tumor differentiation and/or histological grading has been reported for various malignancies. In superficial bladder cancer, abnormally activated PKCa may play a role in tumor differentiation, and elevated PKCa activation correlates with higher histological grade [28]. PKCa is highly expressed in poorlydifferentiated hepatocellular carcinoma cell lines [11]. In melanomas, PKCa activation is typically associated with decreased differentiation [12]. PKCa expression is elevated in high-grade endometrial tumors [19]. In breast cancer, expression of PKCa correlates with high histological grade and proliferation rate [17]. By contrast, one study reported that ovarian carcinoma exhibited decreasing in PKCa expression with increasing histological grade [29]. We found PKCa protein overexpression to be associated with histological grade and tumor differentiation in gastric carcinoma. In addition, we found that PKCa-positive high-grade dysplastic glands, precursor lesions of intestinal type carcinoma, were frequently observed in intestinal type carcinomas with PKCa protein overexpression. The PKCa protein is thus thought to be involved in the early stage of gastric carcinogenesis. PKCa has been thought to play an important role in tumor progression. It has been implicated in several cancer-related processes, such as invasion and metastasis [10]. The role of PKCa in regulating tumor growth and development 23727046 is clearly complex and highly tissue-dependent. In some cases PKCa acts as a tumor promoter, and in others it functions as a tumor suppressor [13]. In current immunohistochemical study, expression of PKCa protein was negatively statistically correlated to depth of invasion, angiolymphatic invasion, pathologic stage, and 
distant metastasis. We thus conduct that PKCa protein acts as a tumor suppressor, and downregulates gastric carcinoma progression. PKCa has been reported to be a prognostic marker in human cancers. In Kong’s study, high level PKCa predicted a shortened recurrence-free survival in patients with superficial bladder carcinomas [28]. Haughian et al demonstrated that PKCa level may be a prognostic indicator of aggressive endometrial cancers [19]. Patients with higher PKCa mRNA expression in hepatocellular carcinomas have a significantly decreased survival rate [21]. For patients with breast cancer, the prognostic significance of PKCa is controversial. L ne et al reported that patients with PKCa-positive breast carcinoma had a poorer survival rate [17], but Kerfoot et al found that PKCa was downregulated in advanced breast carcinoma.
