Product Name: GM2A Polyclonal Antibody, HRP Conjugated
Applications: WB, IHC-P
Reactivity: Human
Conjugation: HRP
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human GM2A/SAP3
Clonality: Polyclonal
CAS NO: 33342-05-1
Product: PF-04929113 (Mesylate)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
Synonyms: SAP-3; GM2-AP; Ganglioside GM2 activator; Cerebroside sulfate activator protein; Sphingolipid activator protein 3; GM2A
Background: The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25237189?dopt=Abstract
