Product Name: GNAS (559CT 16.1.3) Monoclonal Antibody
Applications: WB
Reactivity: Mouse
Conjugation: Unconjugated
Host: Mouse
Sourcr: This GNAS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from human GNAS.
Clonality: Monoclonal
CAS NO: 1156-19-0
Product: TGR-1202 (hydrochloride)
Isotype: IgM
Concentration:
Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Storage: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Synonyms:
Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20144758?dopt=Abstract
