Product Name: GPM6A Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
Applications: FCM
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 647
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human GPM6A
Clonality: Polyclonal
CAS NO: 202914-84-9
Product: Sulfacetamide (sodium monohydrate)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: M6A; GPM6; Neuronal membrane glycoprotein M6-a; GPM6A
Background: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24626220?dopt=Abstract
