Product Name: GPR103 Polyclonal Antibody, FITC Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: FITC
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human G protein coupled receptor 103
Clonality: Polyclonal
CAS NO: 1218942-37-0
Product: NS1643
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: AQ27; G protein coupled receptor 103; G-protein coupled receptor 103; G protein-coupled receptor 103; Orexigenic neuropeptide QRFP receptor; Pyroglutamylated RFamide peptide receptor; QRFP receptor; QRFPR; SP9155; QRFPR_HUMAN; GPCR GPR103.
Background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR103 is a 455-amino acid protein with highest expression in the brain, retina, trigeminal ganglion, hypothalamus and vestibular nucleus. In peripheral tissues, GPR103 is expressed only in the heart, kidney and testis. GPR103 may regulate adrenal function. A hypothalamic neuropeptide of the RFamide family (26RFa) acts as an endogenous ligand for GPR103.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20005634?dopt=Abstract
