Product Name: Glutamyl Prolyl tRNA synthetase Antibody, ALEXA FLUOR® 350 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 350
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human Glutamyl Prolyl tRNA syntase/ProRS
Clonality: Polyclonal
CAS NO: 53716-49-7
Product: XMU-MP-1
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: EARS; PARS; QARS; QPRS; PIG32; GLUPRORS; Bifunctional glutamate/proline–tRNA ligase; Bifunctional aminoacyl-tRNA synthetase; Cell proliferation-inducing gene 32 protein; Glutamatyl-prolyl-tRNA synthetase; EPRS; GLNS
Background: Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23585733?dopt=Abstract
