Product Name: HEXO Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
Applications: IF(IHC-P)
Reactivity: Human
Conjugation: ALEXA FLUOR® 594
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human HEXO
Clonality: Polyclonal
CAS NO: 1353550-13-6
product targets : Histone Acetyltransferase inhibitors
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: HEXO; THEX1; 3HEXO; 3-5 exoribonuclease 1; 3-5 exonuclease ERI1; Eri-1 homolog; Histone mRNA 3-end-specific exoribonuclease; Histone mRNA 3-exonuclease 1; Protein 3hExo; ERI1; 3EXO
Background: RNA exonuclease that binds to the 3-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 and 3-hydroxyl groups at the last nucleotide of the histone 3-end is required for efficient degradation of RNA substrates. Also able to degrade the 3-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5-ACCCA-3 sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24563464?dopt=Abstract
