Product Name: HHV DNA polymerase catalytic subunit Antibody, ALEXA FLUOR® 488 Conjugated
Applications: IF(IHC-P)
Reactivity: Virus
Conjugation: ALEXA FLUOR® 488
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human Human herpesvirus 1 DNA polymerase catalytic subunit
Clonality: Polyclonal
CAS NO: 867160-71-2
LY3023414
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: DPOL_HHV11; DNA polymerase catalytic subunit; UL30; HHV1gp046.
Background: Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5 to 3 direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/28423550?dopt=Abstract
