Product Name: Histone H2A.X (Tyr143) Antibody
Applications: IHC-P, IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Rabbit
Sourcr: KLH conjugated synthetic phosphopeptide derived from human Histone H2AX around the phosphorylation site of Tyr143
Clonality: Polyclonal
CAS NO: 1374639-75-4
BEZ235
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Synonyms: H2AX; H2A.X; H2A/X; Histone H2AX; Histone H2A.X; H2AFX
Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27846905?dopt=Abstract
