Coagulation cascade with Issue VII lipoprotein lipase; cleaves triglycerides arachidonate 5-lipoxygenase; catalyzes leukotriene synthesis toll-like receptor 4; LPS receptor vascular cell adhesion molecule 1; immune response prostaglandin E synthase; prostaglandin synthesis, inflammatory responses, discomfort perception phospholipase D2; cleaves phosphatidyl choline suppressor of cytokine signaling three; damaging regulator of inflammatory response NF-kB inhibitor, alpha; inhibitor of NF-kB- IkBa tenascin N; cartilage and bone formation periostin; osteoblast specific aspect; cell adhesion, mineralization lumican; collagen fibril organization collagen form XVIII a1; a Nimbolide supplier potent antiangiogenic collagen sort IV a1; inhibits endothelial proliferation/angiogenesis collagen variety III a1; soft tissue connected with Collagen form 1 collagen sort XII, a1; fibrillar collagen collagen form IV a2; inhibits endothelial proliferation/angiogenesis collagen, variety VI, alpha three; linkage of matrix/cell collagen, form V, alpha 1; fibrillar collagen ADAM metallopeptidase domain 23; nonproteolytic metalloprotease, cell-cell adhesion serpin peptidase inhibitor, clade E1; inhibits plasminogen activator TIMP metallopeptidase inhibitor two; inhibitor of several MMPs matrix metallopeptidase 14; activates progelatinase MMP 2; ECM breakdown in typical physiologic processes matrix metallopeptidase 11; matrix remodeling, vascular invasion ADAMTS two; cleaves tissue propeptides of collagen form I and II cathepsin D; intracellular proteinase inhibitor TGF beta 2; cell division and development differentiation PDGF receptor, b polypeptide; angiogenesis, cell proliferation and differentiation oncostatin M receptor; increases cartilage degradation PDGF C; wound healing, proliferation and remodeling Insulin Proteins site osteoglycin; Induces bone formation with TGF-beta-1 or TGF-beta-2 epidermal growth factor receptor; cell growth/differentiation WNT1 inducible signaling protein 2; bone turnover Group CD CD CD CD Inf Inf Inf Inf2 Inf2 Inf2 Inf2 Inf2 Inf2 Inf2 Inf2 Inf2 Inf2 Inf2 Inf2 ECM ECM ECM ECM ECM ECM ECM ECM ECM ECM ECM2 ECM2 ECM2 ECM2 ECM2 ECM2 ECM2 ECM2 GF GF GF GF GF GF GFFold adjust OA five 2.28 1.10 1.71 1.36 1.64 2.14 1.26 1.46 7.33 1.66 two.05 1.36 1.82 two.14 two.69 1.40 1.72 1.69 1.42 15.five five.88 4.09 two.71 1.80 two.02 2.ten 1.39 1.30 1.ten three.97 three.27 1.38 1.95 1.01 1.11 1.28 1.61 1.26 1.18 1.85 1.04 1.22 1.29 two.65 OA 9 two.22 1.95 1.98 2.60 two.10 2.40 1.48 four.63 six.00 three.65 two.56 1.58 1.61 1.83 1.82 two.34 two.32 2.09 two.45 18.eight 5.05 5.03 three.92 3.03 3.19 three.11 2.12 two.42 1.73 3.56 three.88 two.19 three.29 1.99 1.47 1.62 two.three two.67 1.77 two.41 2.22 1.19 1.17 five.71 OA 21 2.72 2.56 2.44 2.42 two.98 two.81 2.01 8.59 7.00 4.45 three.14 2.91 2.86 2.85 two.61 2.60 2.49 two.47 2.17 20.9 7.23 5.90 five.66 four.33 three.88 3.42 three.13 two.71 two.12 5.50 four.81 three.07 three.01 two.84 two.39 two.37 2.25 two.63 2.46 2.45 2.15 two.06 2.05 6.Please see Table two for group description. A full list of these genes is given in Table S5. doi:10.1371/journal.pone.0024320.tPLoS One particular www.plosone.orgGene Regulation in the course of MIA ProgressionFigure 6. Molecular networks generated from the genes in each and every cluster by Ingenuity Pathways Evaluation. The molecular networks generated from genes in: (A) Cartilage with Grade 1 harm (Cluster I) Immunological illness network, displaying upregulation of genes linked to acute/innate immune response; (B) Cartilage with Grade 1 damage (Clusters IV) – Skeletal muscular development and function network, displaying downregulation of transcription things and growth factors connected with m.
