390/molecules26195757 Academic Editor: Raffaele Pezzani Received: 21 August 2021 Accepted: 16 September 2021 Published: 23 September10 9Department of Medicinal Chemist and Pharmacognosy, College of Pharmacy, Qassim 5-LOX Inhibitor Storage & Stability University, Qassim 51452, Saudi P2Y14 Receptor drug Arabia; [email protected] Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo 11371, Egypt Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia; [email protected] (S.A.A.M.); [email protected] (M.S.M.S.) Division of Biochemistry, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt Division of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, JUST, Irbid 22110, Jordan Hospital of Police Academy, Nasr city, Cairo 11765, Egypt; mohamedshawky1974@yahoo Division of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt; [email protected] Department of Pharmaceutics, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia; [email protected] Department of Clinical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Abdia, Makkah 21955, Saudi Arabia; [email protected] (S.Y.E.); [email protected] (M.Z.E.-R.) Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; [email protected] Correspondence: [email protected] (H.A.M.); [email protected] (H.M.E.); [email protected] (R.A.K.); Tel.: +00966566176074 (H.A.M.)Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This short article is definitely an open access article distributed below the terms and situations from the Inventive Commons Attribution (CC BY) license ( creativecommons.org/licenses/by/ 4.0/).Abstract: Sage, Salvia officinalis L., is utilized worldwide as an aromatic herb for culinary purposes at the same time as a traditional medicinal agent for various ailments. Existing investigations exhibited the effects of extended dryings of the herb around the yields, composition, oil excellent, and hepatoprotective at the same time as anti-cancer biological activities in the hydrodistillation-obtained vital oils in the aerial components of the plant. The essential oils’ yields, compositions, and biological activities levels of your fresh and differently timed and room-temperature dried herbs differed considerably. The lowest yields with the vital oil were obtained in the fresh herbs (FH, 631 mg, 0.16 ), though the highest yield was obtained from the two-week dried herbs (2WDH, 1102 mg, 0.28 ). A notable lower in monoterpenes, with increment inside the sesquiterpene constituents, was observed for the FH-based important oil as in comparison to each of the other batches of the critical oils obtained in the differenttimed dried herbs. Additionally, characteristic chemotypic constituents of sage, i.e., -pinene, camphene, -pinene, myrcene, 1, 8-cineole, -thujone, and camphor, had been present in substantially higher proportions in each of the dried herbs’ essential oils as when compared with the FH-based necessary oil. The in vivo hepatoprotective activity demonstrated substantial reductions inside the levels of AST, ALT, and ALP, as well as a important improve in the total protein (p 0.05) contents level, as in comparison with the acetaminophen (AAP) administered experimental group of rats. A significant reduction (p 0.05) within the ALT level was demonstrated by the 4W
