Tion of hardness, thickness and diameter had been presented (n=10). Study of
Tion of hardness, thickness and diameter have been presented (n=10). Study of water uptake and erosion: To be able to evaluate the water uptake and erosion of each tablet, the tablets have been individually weighed prior to dissolution testing as original dry weight. Right after dissolution test, every single tablet was blotted to eliminate excess water and right away weighed on analytical balance as wet weight after which all of them had been dried at 60for 24 h and kept in desiccator for a minimum of three days and individually weighed as remaining dry weight. Water uptake and erosion wereMATERIALS AND METHODSHydrochlorothiazide (HCT, batch No I 1413891 was supplied by Government of Pharmaceutical Organization, Thailand). Propranolol HCl (PRO, lot no M080311, Pc Drug Co., Ltd., Bangkok, Thailand), Lutrol F127 (L) (lot no WPDF563B, BASF, Ludwigshafen, Germany) and shellac wax (S) (Ake Shellac Co., Ltd., Lumpang, Thailand) were utilised as received. Ethylene glycol (lot no.1341646,January – FebruaryIndian Journal of Pharmaceutical Sciencesijpsonlineevaluated gravimetrically in line with the following Eqns., water uptake=(wet weight emaining dry weight)remaining dry weight)00….(Eqn. 1) and erosion=((original dry weight emaining dry weight)original dry weight)00….(Eqn. two) Determination of make contact with angle and surface no cost power (SFE): Speak to angle could describe the wettability of any compound in the formulation. Additionally, it was utilized to calculate the SFE of these compounds. SFE could possibly be applied to describe several properties of compounds which include polarity or the miscibility of mixed element [21]. Within this experiment, SFE was calculated applying Wu’s Eqn., expressed under.(1 COS ) 1 = 4( 1d 2 d ) four( 1 p two p ) p 1d two d 1 2pThe cumulative drug Dopamine Receptor site release of PRO or HCT were calculated and plotted against time. The dissolution of combined PRO and HCT matrix tablets had been studied using the process as previously described. Having said that, the level of drug release was determined working with first derivative UVspectroscopy technique (FUV). Drug release amount was determined at 297 and 336 nm for PRO and HCT, respectively. The cumulative drug release of PRO and HCT had been calculated and plotted against time. The simultaneous determination of two drugs content material was measured with FUV as well as the obtained spectra (D1) at 297 and 336 nm for PRO and HCT, respectively, was employed for this study. Selection of linearity of PRO and HCT was 1.5-7.five (r 2=0.9999) and 3.6-18.0 ml (r 2=0.9996), respectively. Recovery of PRO and HCT was 106.59 and 97.11, respectively. FGFR3 manufacturer precision was determined as intraday and interday precision. The RSD of intraday precision was 2.46 and 1.88 for PRO and HCT, respectively. For interday precision, the RSD was two.23 and 1.57 for PRO and HCT, respectively. LOD of typical curve was discovered to be 0.ten and 0.49 ml for PRO and HCT, respectively. LOQ was 0.31 and 1.48 ml for PRO and HCT, respectively. Mechanisms of drug release had been evaluated by fitting of cumulative drug release information with mathematical release models. The models employed within this experiment had been zero order, first order, Higuchi’s model, power law expression and Hixson-Crowell cube root equation. The experimental cumulative drug release information within the array of 10-80 have been employed to evaluate the kinetic of drug release by least square fitting system. The information had been fitted with all the mathematical Eqns by nonlinear personal computer programme, Scientist for Windows, version 2.1[22]. The coefficient of determination (r2) was made use of to indicate the degree of.
