Level was discovered in between the end with the second three months and
Level was found amongst the end on the second 3 months as well as the baseline (p = 0.106) (Figure two). For group 2, the hs-CRP level remained unchanged at the end on the 1st 3 months (p = 0.663) compared with that in the baseline. Having said that, it was significantly decreased in the end on the second three months compared with that in the baseline (p = 0.005) plus the end on the initial three months (p 0.001) (Figure 2).p0.001 p=0.For group 1, levels of prealbumin and albumin exhibited a slight enhance (p 0.05) in the end in the first three months compared with these in the baseline. Immediately after the vitamin C 5-HT7 Receptor Modulator MedChemExpress supplementation was withdrawn, levels of prealbumin and albumin (p 0.05) have been decreased at the end on the second 3 months (Table two). For group 2, levels of prealbumin and albumin remained unchanged in the finish with the very first 3 months (p 0.05) compared with these at the baseline. Having said that, a important enhance in prealbumin (p = 0.018) and an increase trend in albumin (p 0.05) have been observed in the finish of the second three months compared with these in the end with the initial 3 months (Table two).Alter of ERI for the duration of the studyFor group 1, a reduce trend in ERI, ferritin and EPO dosage (all p 0.05) and a rise trend in hemoglobin (p 0.05) were observed in the finish on the initially three monthsp=0.hsCRP(mgl)60 40 20 0 0 39.6(six.0,13.8) 4.9(3.7,eight.7) eight.1(five.1,11.3)hsCRP��mgl��p0.60 40 20 0 0 36.2(4.two,11.0) 7.1(five.2,8.eight) 5.1(two.6,6.five)time (month)time (month)GroupGroupFigure 2 Effect of vitamin C supplementation on plasma hs-CRP level. Group 1: patients were orally administered with 200 mgday vitamin C through the initial three months, and also the vitamin C administration was 5-HT6 Receptor Modulator Storage & Stability withdrawn thereafter. Group two: individuals have been administered with vitamin C during the second 3 months. Hs-CRP level was presented as Median (IQR); levels of hs-CRP have been compared among groups working with Kruskal Wallis Test.Zhang et al. BMC Nephrology 2013, 14:252 http:biomedcentral1471-236914Page five ofTable 2 Impact of vitamin C supplementation on parameters through 6 months (n = one hundred)Item prealbumin (mgl) albumin (gl) hemoglobin (gl) ERI Ferritin (ugl) Vitamin C (gmL)Group 1 (n = 48) Baseline 295.six 86.6 38.2 three.7 107.2 16.six ten.7 8.six 417.eight 266.5 1.five 0.8 Month three 296.7 60.1 38.three 3.1 109.9 14.1 eight.3 six.6 355.0 256.4 ten.4 ten.bGroup 2 (n = 52) Month 6 272.1 69.three 37.six 2.six 109.3 14.two 9.1 7.four 444.two 333.5 2.1 1.cBaseline 315.3 85.eight 40.0 four.two 111.four 17.3 9.3 6.1 461.9 287.1 2.0 0.Month 3 302.9 60.three 39.six 2.eight 110.9 20.four eight.6 6.7 500.0 314.2 2.1 1.three Median(IQR)Month six 336.9 69.5a 40.four two.4 111.9 25.4 7.five 6.4 445.9 352.7 9.1 four.3bcMedian(IQR) rHuEpo (x10 Uweek) hsCRP (mgl)a6.0(3.0-9.0) 9.6 (6.0-13.eight)b4.five(2.8-6.0) four.9(three.7-8.7)b5.2(two.6-8.8) eight.1(5.1-11.three)dc6.0(4.0-8.8) 6.two(4.2-11.0)six.0(3.0-8.eight) 7.1(five.2-8.eight)d4.two(2.7-6.0) 5.1(two.6-6.five)bcNote: p 0.05:compared with group baseline; p 0.01:compared with group baseline; p 0.01:compared with group Month three; p 0.05:compared with group Month 3; prealbumin, albumin, hemoglobin, ERI, ferritin and vitamin C levels were presented as imply SD; EPO dosage and hs-CRP level have been presented as median and inter-quartile range (IQR). Abbreviations: ERI EPO resistance index, rHuEpo, recombinant human erythropoietin, hs-CRP higher hypersensitive C-reactive protein, IQR inter quartile rangepared with these at the baseline. In the end in the second 3 months, ERI, ferritin and EPO dosage (all p 0.05) had been elevated with out statistical significance compared with those at the finish from the initial three months, whereas the hemoglobin level rema.
