= 0.47 P = 0.0038i P = 0.050ii P = 0.81 P = 0.37 P = 0.19 P = 0.35 P = 0.28 P = 0.Interaction P = 0.30 P = 0.43 P = 0.22 P = 0.61 P = 0.7588 231 497.9 15.7 15.35 0.98 68.27 0.85 two.60 0.16 9.15 1.a7296 228 487.8 15.4 15.53 0.96 68.09 0.84 two.88 0.16 ten.30 1.34 86.10 1.70c 2618 170 17.37 3.28 2.32 1.9069 238 626.7 16.1 48.23 1.01 39.75 0.87 three.49 0.16 15.97 1.38 78.46 1.35b 3055 176 1.21 3.34 six.19 1.9.22 1.18.60 1.P = 0.0053 P = 0.87.47 1.73c 2580 173 17.69 3.40 0.90 1.85.41 1.72c 2364 171 23.54 three.32 0.83 1.84.04 1.76c 2540 176 18.46 3.42 1.00 1.73.05 1.44a 2740 184 1.15 three.50 five.92 1.72.94 1.62a 2544 174 4.32 three.31 four.09 1.76.56 1.48b 3074 189 1.45 three.59 five.57 1.P 0.0001 P = 0.017 P = 0.0003 P = 0.P = 0.46 P = 0.77 P = 0.Distinct letters represent significance amongst suggests as determined by Bonferroni correction (P 0.05). Genotype Impact: Lean Obese; Obese Lean. Eating plan Effect: iCON, FLAX, FISH SDA; iiSDA CON, FLAX, FISH.Page 4 ofCasey et al. Lipids in Health and Disease 2013, 12:147 http://www.lipidworld/content/12/1/Page five ofFigure 1 Serum cholesterol and triacylglyceride concentrations in LZR and OZR rats offered CON, FLAX, FISH, or SDA diets for 12 weeks. All graphed values represent LS interaction suggests SE. Letters represent substantial differences amongst implies as determined by the Bonferroni correction. A) Serum cholesterol expressed as mmol/L (n = six, Genotype effect, P 0.0001 (Obese Lean); Diet regime impact, P 0.0001 (CON, FLAX FISH, SDA); Diet*Genotype interaction, P = 0.094). B) Serum triacylglyceride expressed as mmol/L (n = 6, Genotype effect, P = 0.0002 (Obese Lean); Diet plan impact, P = 0.0065 (CON, FLAX FISH, SDA); Diet*Genotype interaction, P = 0.93).effect of diet program on these variables (Eating plan, P = 0.35, P = 0.28 and P = 0.25, respectively).Hepatic metabolic profileErythrocyte membrane fatty acid compositionIn erythrocytes, the percentage of EPA, DHA, MUFA, and n3PUFA had been higher; whereas, LA and n6PUFA have been reduced in obese vs. lean rodents (Table 3; Genotype, P 0.001). All n3PUFA-enriched diets (FLAX, FISH, and SDA) enhanced omega-3 index in OZR rats (Figure two; Genotype*Diet, P 0.0001). Additionally, the percentage of EPA, DPA, and n3PUFA have been greater; whereas, AA and n6PUFA were lower with FLAX, FISH, or SDA vs. CON (Diet plan, P 0.0001). Omega-3 index, as well because the percentage of EPA, DHA, and n3PUFA, was greatest with FISH when compared with remaining n3PUFA-enriched diets (Diet, P 0.0001). In contrast, the percentage of GLA, SDA, and DPA had been greatest with SDA (Eating plan, P 0.0001). The SDA diet program also resulted within a greater percentage of EPA and n3PUFA, as well as a decrease percentage of LA, AA, and n6PUFA compared to FLAX (Diet, P 0.Orteronel 0001).Pertuzumab Liver weight and fat content material have been greater; even though, lean mass was decrease in obese vs.PMID:23891445 lean rodents (Table 2; Genotype, P 0.0001). Independently of genotype, there was no substantial distinction in liver weight (Eating plan, P = 0.81), fat content (Diet program, P = 0.37) or lean mass (Diet, P = 0.19). Nevertheless, hepatic fat content material in obese rodents was unexpectedly higher with FLAX vs. FISH or SDA (Gen*Diet, P 0.0001). In contrast, the hepatic lean mass in OZR rats was reduce with CON and FLAX when compared with SDA or FISH (Gen*Diet, P 0.05).Hepatic fatty acid compositionThe percentage of ALA, AA, DPA, DHA, MUFA, n3PUFA, and n6PUFA had been decrease, whereas SFA was higher in liver of obese vs. lean rodents (Table 4; Genotype, P 0.05). All n3PUFA-enriched diets had a greater percentage of DPA, DHA, and n3PUFA, too as lower percentage of.
