E mixture was administered when day-to-day at 9 pm, concomitant latanoprost + timolol was administered twice daily at 9 am (timolol only) and 9 pm (latanoprost + timolol), latanoprost monotherapy was administered as soon as each day at 9 pm, and timolol monotherapy was administered twice day-to-day at 9 am and 9 pm. Information shown are in the efficacy analysis (ITT) population. Last observation carried forward was applied for missing observations. Abbreviations: iOP, intraocular stress; iTT, intent to treat.submit your manuscript | www.dovepressClinical Ophthalmology 2014:DovepressDovepress100 90 80BAK-free latanoprost/timolol fixed-dose mixture in OAG and OHTPercentage ( )60 50 40 30 20 10* *Latanoprost/timolol fixed-dose combination Latanoprost + timolol Latanoprost TimololTreatment Remedy groupLatanoprost/timolol fixed-dose combination (n=55) Latanoprost + timolol (n=56) Latanoprost (n=54) Timolol (n=56)Responders, n ( ) P-value43 (78.two)42 (75.0) 0.31 (57.four) 0.0202*26 (46.4) 0.0006*Figure 3 Responder prices (defined as patients obtaining IOP 18 mmHg for no less than two time points at every follow-up check out) for the four treatment groups. Notes: P-values have been calculated utilizing chi-square test for comparing remedy groups (every single treatment group versus latanoprost/timolol fixed-dose combination group). Data shown are from the efficacy analysis (ITT) population. *indicates a statistically considerable P-value. Abbreviations: iOP, intraocular stress; iTT, intent to treat.Table three summary of ocular Teaes reported through the course in the study (safety population)Program Organ Class/ Preferred Term Total variety of TEAEs, n Total number of sufferers with no less than one TEAE, n ( )* Sufferers reporting TEAEs in all probability associated to therapy, n ( ) Sufferers reporting TEAEs possibly connected to therapy, n ( ) Sufferers reporting TEAEs unlikely or not related to remedy, n ( ) eye disorders, n ( ) Conjunctival hyperemia Conjunctivitis Corneal disorder Diabetic retinopathy Dry eye eye irritation eye pain eye pruritus Foreign body sensation in eyes lacrimation enhanced Macular edema Ocular hyperemia Photophobia Visual acuity lowered Remedy group Latanoprost/timolol fixeddose mixture (n=56) 23 12 (21.Tacrolimus 4) 1 (1.Tusamitamab ravtansine eight) 8 (14.PMID:25269910 3) three (5.4) 12 (21.4) 1 (1.8) 2 (3.6) 0 0 3 (5.four) four (7.1) four (7.1) two (3.6) 1 (1.eight) two (three.6) 0 2 (3.6) 2 (3.6) 0 Latanoprost + timolol (n=58) 14 ten (17.2) two (3.4) five (8.6) 3 (five.two) ten (17.two) three (5.two) 0 0 0 1 (1.7) 6 (ten.3) two (3.four) 1 (1.7) 1 (1.7) 0 0 0 0 0 Latanoprost (n=55) 15 8 (14.five) 0 three (five.5) 5 (9.1) 8 (14.5) 0 2 (3.6) 1 (1.eight) 0 1 (1.8) two (3.6) 2 (3.6) 1 (1.eight) 2 (3.6) 1 (1.eight) 1 (1.8) 0 1 (1.8) 1 (1.8) Timolol (n=58) 16 9 (15.five) 0 six (10.three) three (5.2) 9 (15.5) 1 (1.7) 0 0 1 (1.7) two (3.4) five (eight.6) three (five.2) 0 0 1 (1.7) 1 (1.7) 0 0 0 All round (n=227) 68 39 (17.2) 3 (1.three) 22 (9.7) 14 (six.2) 39 (17.2) 5 (2.two) four (1.8) 1 (0.4) 1 (0.4) 7 (3.1) 17 (7.five) 11 (4.8) 4 (1.eight) 4 (1.eight) 4 (1.8) two (0.9) 2 (0.9) three (1.three) 1 (0.4)Notes: *All ocular TEAEs had been mild or moderate in nature. Patients may perhaps have reported a lot more than one event per Method Organ Class or Preferred Term. Sufferers have been counted once for every System Organ Class or Preferred Term at the maximum intensity/relationship experienced. Abbreviation: TEAE, treatment-emergent adverse occasion.Clinical Ophthalmology 2014:submit your manuscript | www.dovepressDovepressBhagat et alDovepressTable four summary of nonocular Teaes reported during the course on the study (security population)Method Organ Class/ Preferred Term Total number of T.
