Product Name :
Thiostrepton, Streptomyces laurentii, 90+%
Synonym:
IUPAC Name :
CAS NO.:
1393-48-2
Molecular Weight :
Molecular formula:
Smiles:
Description:
Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis.Nociceptin Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies.Nimesulide Thiostrepton is an inhibitor of FOXM1.PMID:24458656 Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures.
