Product Name :
Lopinavir-d8
Description:
Lopinavir-d8 (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.
CAS:
1224729-35-4
Molecular Weight:
636.85
Formula:
C37H48N4O5
Chemical Name:
N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-(²H₃)methyl-2-(2-oxo-1,3-diazinan-1-yl)(²H₅)butanamide
Smiles :
[2H]C(C([2H])(C(=O)N[C@H](C[C@H](O)[C@H](CC1C=CC=CC=1)NC(=O)COC1C(C)=CC=CC=1C)CC1C=CC=CC=1)N1CCCNC1=O)(C([2H])([2H])[2H])C([2H])([2H])[2H]
InChiKey:
KJHKTHWMRKYKJE-JOYHXWCXSA-N
InChi :
InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34?/m0/s1/i1D3,2D3,25D,34D
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{IPTG} MedChemExpress|{IPTG} {Biochemical Assay Reagents}|{IPTG} Technical Information|{IPTG} Purity|{IPTG} manufacturer|{IPTG} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lopinavir-d8 (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.|Product information|CAS Number: 1224729-35-4|Molecular Weight: 636.{{Flucytosine} MedChemExpress|{Flucytosine} Fungal|{Flucytosine} Technical Information|{Flucytosine} In stock|{Flucytosine} custom synthesis|{Flucytosine} Autophagy} 85|Formula: C37H48N4O5|Chemical Name: N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-(²H₃)methyl-2-(2-oxo-1,3-diazinan-1-yl)(²H₅)butanamide|Smiles: [2H]C(C([2H])(C(=O)N[C@H](C[C@H](O)[C@H](CC1C=CC=CC=1)NC(=O)COC1C(C)=CC=CC=1C)CC1C=CC=CC=1)N1CCCNC1=O)(C([2H])([2H])[2H])C([2H])([2H])[2H]|InChiKey: KJHKTHWMRKYKJE-JOYHXWCXSA-N|InChi: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34?/m0/s1/i1D3,2D3,25D,34D|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23910527 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.|Products are for research use only. Not for human use.|
