Product Name :
Tussilagone
Description:
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice.
CAS:
104012-37-5
Molecular Weight:
390.51
Formula:
C23H34O5
Chemical Name:
(1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]-4-methylidene-2-oxo-7-(propan-2-yl)-octahydro-1H-inden-5-yl (2E)-3-methylpent-2-enoate
Smiles :
CC(C)[C@@H]1C[C@@H](OC(=O)/C=C(\C)/CC)C(=C)[C@@H]2CC(=O)[C@@H]([C@H]21)[C@@H](C)OC(C)=O
InChiKey:
CFUPNMDNSQIWBB-UUVDBSHOSA-N
InChi :
InChI=1S/C23H34O5/c1-8-13(4)9-21(26)28-20-11-17(12(2)3)23-18(14(20)5)10-19(25)22(23)15(6)27-16(7)24/h9,12,15,17-18,20,22-23H,5,8,10-11H2,1-4,6-7H3/b13-9+/t15-,17+,18+,20-,22+,23+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bivalirudin} MedChemExpress|{Bivalirudin} Thrombin|{Bivalirudin} Purity & Documentation|{Bivalirudin} In Vitro|{Bivalirudin} supplier|{Bivalirudin} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Anacardic Acid} site|{Anacardic Acid} Epigenetics|{Anacardic Acid} Biological Activity|{Anacardic Acid} Purity|{Anacardic Acid} manufacturer|{Anacardic Acid} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice.|Product information|CAS Number: 104012-37-5|Molecular Weight: 390.51|Formula: C23H34O5|Chemical Name: (1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]-4-methylidene-2-oxo-7-(propan-2-yl)-octahydro-1H-inden-5-yl (2E)-3-methylpent-2-enoate|Smiles: CC(C)[C@@H]1C[C@@H](OC(=O)/C=C(\C)/CC)C(=C)[C@@H]2CC(=O)[C@@H]([C@H]21)[C@@H](C)OC(C)=O|InChiKey: CFUPNMDNSQIWBB-UUVDBSHOSA-N|InChi: InChI=1S/C23H34O5/c1-8-13(4)9-21(26)28-20-11-17(12(2)3)23-18(14(20)5)10-19(25)22(23)15(6)27-16(7)24/h9,12,15,17-18,20,22-23H,5,8,10-11H2,1-4,6-7H3/b13-9+/t15-,17+,18+,20-,22+,23+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.PMID:28739548 5 mg/mL (160.05 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages.|In Vivo:|Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration.|Products are for research use only. Not for human use.|
