Product Name :
Propargyl-PEG4-Tos
Description:
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
CAS:
875770-32-4
Molecular Weight:
386.46
Formula:
C18H26O7S
Chemical Name:
3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate
Smiles :
CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCC#C
InChiKey:
VUJIUZITHCTEAF-UHFFFAOYSA-N
InChi :
InChI=1S/C18H26O7S/c1-3-8-21-9-10-22-11-12-23-13-14-24-15-16-25-26(19,20)18-6-4-17(2)5-7-18/h1,4-7H,8-16H2,2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.{{Rhodamine B} MedChemExpress|{Rhodamine B} {Fluorescent Dye}|{Rhodamine B} Biological Activity|{Rhodamine B} Data Sheet|{Rhodamine B} custom synthesis|{Rhodamine B} Cancer} Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).|Product information|CAS Number: 875770-32-4|Molecular Weight: 386.46|Formula: C18H26O7S|Chemical Name: 3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate|Smiles: CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCC#C|InChiKey: VUJIUZITHCTEAF-UHFFFAOYSA-N|InChi: InChI=1S/C18H26O7S/c1-3-8-21-9-10-22-11-12-23-13-14-24-15-16-25-26(19,20)18-6-4-17(2)5-7-18/h1,4-7H,8-16H2,2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.{{Estriol} MedChemExpress|{Estriol} Vitamin D Related/Nuclear Receptor|{Estriol} Biological Activity|{Estriol} In Vitro|{Estriol} supplier|{Estriol} Cancer} PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.PMID:35901518 ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|References:|Wurz RP, et al. A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.Senthilkumar T, et al. Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled DrugDelivery, Release, and Imaging. Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13114-13119.Products are for research use only. Not for human use.|
