Product Name :
DM1-SMe
Description:
DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC).
CAS:
138148-68-2
Molecular Weight:
784.38
Formula:
C36H50ClN3O10S2
Chemical Name:
N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine
Smiles :
C[C@@]12OC1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1C=C(OC)C(Cl)=C(C=1)N(C)C(=O)C[C@H]2OC(=O)[C@H](C)N(C)C(=O)CCSSC)OC |c:17,19|
InChiKey:
ZLUUPZXOPGORNG-RKOIAADPSA-N
InChi :
InChI=1S/C36H50ClN3O10S2/c1-20-11-10-12-27(47-8)36(45)19-26(48-34(44)38-36)21(2)32-35(4,50-32)28(49-33(43)22(3)39(5)29(41)13-14-52-51-9)18-30(42)40(6)24-16-23(15-20)17-25(46-7)31(24)37/h10-12,16-17,21-22,26-28,32,45H,13-15,18-19H2,1-9H3,(H,38,44)/b12-10-,20-11-/t21-,22+,26+,27-,28-,32?,35+,36+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC).{{M-CSF Protein, Rat} medchemexpress|{M-CSF Protein, Rat} Biological Activity|{M-CSF Protein, Rat} References|{M-CSF Protein, Rat} manufacturer|{M-CSF Protein, Rat} Epigenetics} |Product information|CAS Number: 138148-68-2|Molecular Weight: 784.38|Formula: C36H50ClN3O10S2|Chemical Name: N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine|Smiles: C[C@@]12OC1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1C=C(OC)C(Cl)=C(C=1)N(C)C(=O)C[C@H]2OC(=O)[C@H](C)N(C)C(=O)CCSSC)OC |c:17,19||InChiKey: ZLUUPZXOPGORNG-RKOIAADPSA-N|InChi: InChI=1S/C36H50ClN3O10S2/c1-20-11-10-12-27(47-8)36(45)19-26(48-34(44)38-36)21(2)32-35(4,50-32)28(49-33(43)22(3)39(5)29(41)13-14-52-51-9)18-30(42)40(6)24-16-23(15-20)17-25(46-7)31(24)37/h10-12,16-17,21-22,26-28,32,45H,13-15,18-19H2,1-9H3,(H,38,44)/b12-10-,20-11-/t21-,22+,26+,27-,28-,32?,35+,36+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Nicotinamide} medchemexpress|{Nicotinamide} Cell Cycle/DNA Damage|{Nicotinamide} Biological Activity|{Nicotinamide} Data Sheet|{Nicotinamide} supplier|{Nicotinamide} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:34856019 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Wood AC, Maris JM, Gorlick R, Kolb EA, Keir ST, Reynolds CP, Kang MH, Wu J, Kurmasheva RT, Whiteman K, Houghton PJ, Smith MA. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013 Nov;60(11):1860-7. doi: 10.1002/pbc.24647. Epub 2013 Jun 24. PubMed PMID: 23798344; PubMed Central PMCID: PMC4260400.Products are for research use only. Not for human use.|
