Product Name :
HBX41108, USP7 Inhibitor
Description:
HBX41108 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM. Kinetics data indicate it is an uncompetitive reversible inhibition mechanism. It inhibits USP7-mediated p53 deubiquitination (IC50 ~0.8 μM). It can also stabilize p53 and activate the transcription of a p53 target gene without inducing genotoxic stress. HBX41108 inhibits cancer cell growth, and induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
CAS:
924296-39-9
Molecular Weight:
266.64
Formula:
C13H3ClN4O
Chemical Name:
HBX41108, USP7 Inhibitor
Smiles :
N#CC1=NC2=C(N=C1C#N)C(=O)C1=CC(Cl)=CC=C12
InChiKey:
BIGPXXAUSQLTQR-UHFFFAOYSA-N
InChi :
InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Vitamin D2} site|{Vitamin D2} VD/VDR|{Vitamin D2} Biological Activity|{Vitamin D2} Data Sheet|{Vitamin D2} supplier|{Vitamin D2} Epigenetics}
Additional information:
HBX41108 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM. Kinetics data indicate it is an uncompetitive reversible inhibition mechanism. It inhibits USP7-mediated p53 deubiquitination (IC50 ~0.8 μM). It can also stabilize p53 and activate the transcription of a p53 target gene without inducing genotoxic stress. HBX41108 inhibits cancer cell growth, and induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.|Product information|CAS Number: 924296-39-9|Molecular Weight: 266.64|Formula: C13H3ClN4O|Chemical Name: HBX41108, USP7 Inhibitor|Smiles: N#CC1=NC2=C(N=C1C#N)C(=O)C1=CC(Cl)=CC=C12|InChiKey: BIGPXXAUSQLTQR-UHFFFAOYSA-N|InChi: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{N-Acetyloxytocin} medchemexpress|{N-Acetyloxytocin} Endogenous Metabolite|{N-Acetyloxytocin} Purity & Documentation|{N-Acetyloxytocin} References|{N-Acetyloxytocin} custom synthesis|{N-Acetyloxytocin} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:25105126 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|HBX41108 was used at 10 µM final concentration in various in vitro assays.|References:|Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. (2009) Mol Cancer Ther. 8(8):2286-95.Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. (2010) ChemMedChem. 5(4):552-8.Products are for research use only. Not for human use.|Documents||
