Product Name :
Way-262611
Description:
WAY262611 HCl is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3.
CAS:
1123231-07-1
Molecular Weight:
391.34
Formula:
C20H24Cl2N4
Chemical Name:
(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine Dihydrochloride
Smiles :
Cl.Cl.NCC1CCN(CC1)C1=NC(=CC=N1)C1=CC2=CC=CC=C2C=C1
InChiKey:
VKWQTBHLUZTWQS-UHFFFAOYSA-N
InChi :
InChI=1S/C20H22N4.2ClH/c21-14-15-8-11-24(12-9-15)20-22-10-7-19(23-20)18-6-5-16-3-1-2-4-17(16)13-18;;/h1-7,10,13,15H,8-9,11-12,14,21H2;2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Argireline} MedChemExpress|{Argireline} Protocol|{Argireline} Formula|{Argireline} manufacturer|{Argireline} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
WAY262611 HCl is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3.|Product information|CAS Number: 1123231-07-1|Molecular Weight: 391.34|Formula: C20H24Cl2N4|Synonym:|WAY-262611 2HCl|WAY-262611 dihydrochloride|WAY262611 2HCl|WAY 262611 dihydrochloride|WAY-262611 dihydrochloride WAY 262611 dihydrochloride|Chemical Name: (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine Dihydrochloride|Smiles: Cl.Cl.NCC1CCN(CC1)C1=NC(=CC=N1)C1=CC2=CC=CC=C2C=C1|InChiKey: VKWQTBHLUZTWQS-UHFFFAOYSA-N|InChi: InChI=1S/C20H22N4.2ClH/c21-14-15-8-11-24(12-9-15)20-22-10-7-19(23-20)18-6-5-16-3-1-2-4-17(16)13-18;;/h1-7,10,13,15H,8-9,11-12,14,21H2;2*1H|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tixagevimab} MedChemExpress|{Tixagevimab} SARS-CoV|{Tixagevimab} Biological Activity|{Tixagevimab} References|{Tixagevimab} custom synthesis|{Tixagevimab} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:25023702 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.|In Vivo:|WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1.|References:|Polakis P. Wnt signaling and cancer. Genes Dev. 2000 Aug 1;14(15):1837-51. Review. PubMed PMID: 10921899.Products are for research use only. Not for human use.|
