Product Name :
Clozapine D8
Description:
Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
CAS:
1185053-50-2
Molecular Weight:
334.87
Formula:
C18H19ClN4
Chemical Name:
6-chloro-10-[4-methyl(2,2,3,3,5,5,6,6-²H₈)piperazin-1-yl]-2,9-diazatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaene
Smiles :
[2H]C1([2H])N(C)C([2H])([2H])C([2H])([2H])N(C2=NC3=CC(Cl)=CC=C3NC3=CC=CC=C32)C1([2H])[2H]
InChiKey:
QZUDBNBUXVUHMW-JNJBWJDISA-N
InChi :
InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3/i8D2,9D2,10D2,11D2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{DOTAP} web|{DOTAP} Liposome|{DOTAP} Immunology/Inflammation|{DOTAP} Protocol|{DOTAP} In Vitro|{DOTAP} manufacturer}
Shelf Life:
≥12 months if stored properly.{{Scutellarin} web|{Scutellarin} JAK/STAT Signaling|{Scutellarin} Biological Activity|{Scutellarin} In stock|{Scutellarin} custom synthesis|{Scutellarin} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:28322188
Additional information:
Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).|Product information|CAS Number: 1185053-50-2|Molecular Weight: 334.87|Formula: C18H19ClN4|Chemical Name: 6-chloro-10-[4-methyl(2,2,3,3,5,5,6,6-²H₈)piperazin-1-yl]-2,9-diazatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaene|Smiles: [2H]C1([2H])N(C)C([2H])([2H])C([2H])([2H])N(C2=NC3=CC(Cl)=CC=C3NC3=CC=CC=C32)C1([2H])[2H]|InChiKey: QZUDBNBUXVUHMW-JNJBWJDISA-N|InChi: InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3/i8D2,9D2,10D2,11D2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
