Product Name :
TASP0415914
Description:
TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research.
CAS:
1292300-75-4
Molecular Weight:
323.37
Formula:
C13H17N5O3S
Chemical Name:
N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide
Smiles :
CC1N=C(NC(C)=O)SC=1C1=NC(=NO1)N1CC(O)CCC1
InChiKey:
WFQFHKQIDOCQTL-UHFFFAOYSA-N
InChi :
InChI=1S/C13H17N5O3S/c1-7-10(22-13(14-7)15-8(2)19)11-16-12(17-21-11)18-5-3-4-9(20)6-18/h9,20H,3-6H2,1-2H3,(H,14,15,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Piracetam} web|{Piracetam} iGluR|{Piracetam} Purity & Documentation|{Piracetam} In Vitro|{Piracetam} custom synthesis|{Piracetam} Epigenetic Reader Domain}
Additional information:
TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM.{{ETZ} web|{ETZ} {Fluorescent Dye}|{ETZ} Technical Information|{ETZ} In stock|{ETZ} custom synthesis|{ETZ} Epigenetics} TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM.PMID:25269910 TASP0415914 can be used for inflammatory diseases research.|Product information|CAS Number: 1292300-75-4|Molecular Weight: 323.37|Formula: C13H17N5O3S|Chemical Name: N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide|Smiles: CC1N=C(NC(C)=O)SC=1C1=NC(=NO1)N1CC(O)CCC1|InChiKey: WFQFHKQIDOCQTL-UHFFFAOYSA-N|InChi: InChI=1S/C13H17N5O3S/c1-7-10(22-13(14-7)15-8(2)19)11-16-12(17-21-11)18-5-3-4-9(20)6-18/h9,20H,3-6H2,1-2H3,(H,14,15,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (386.55 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4.|In Vivo:|TASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model.|Products are for research use only. Not for human use.|
