Product Name :
Thalidomide-O-C8-NH2
Description:
Thalidomide-O-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
CAS:
1957235-91-4
Molecular Weight:
401.46
Formula:
C21H27N3O5
Chemical Name:
4-[(8-aminooctyl)oxy]-2-(2, 6-dioxopiperidin-3-yl)-2, 3-dihydro-1H-isoindole-1, 3-dione
Smiles :
NCCCCCCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey:
AIGGDIVRTBLYIR-UHFFFAOYSA-N
InChi :
InChI=1S/C21H27N3O5/c22-12-5-3-1-2-4-6-13-29-16-9-7-8-14-18(16)21(28)24(20(14)27)15-10-11-17(25)23-19(15)26/h7-9,15H,1-6,10-13,22H2,(H,23,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thalidomide-O-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.|Product information|CAS Number: 1957235-91-4|Molecular Weight: 401.46|Formula: C21H27N3O5|Chemical Name: 4-[(8-aminooctyl)oxy]-2-(2, 6-dioxopiperidin-3-yl)-2, 3-dihydro-1H-isoindole-1, 3-dione|Smiles: NCCCCCCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: AIGGDIVRTBLYIR-UHFFFAOYSA-N|InChi: InChI=1S/C21H27N3O5/c22-12-5-3-1-2-4-6-13-29-16-9-7-8-14-18(16)21(28)24(20(14)27)15-10-11-17(25)23-19(15)26/h7-9,15H,1-6,10-13,22H2,(H,23,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{TOPS} medchemexpress|{TOPS} {Biochemical Assay Reagents}|{TOPS} Technical Information|{TOPS} References|{TOPS} manufacturer|{TOPS} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Chlorogenic acid} web|{Chlorogenic acid} Metabolic Enzyme/Protease|{Chlorogenic acid} Technical Information|{Chlorogenic acid} Description|{Chlorogenic acid} custom synthesis|{Chlorogenic acid} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32809727 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.Products are for research use only. Not for human use.|
