Product Name :
Artesunate
Description:
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
CAS:
88495-63-0
Molecular Weight:
384.42
Formula:
C19H28O8
Chemical Name:
4-oxo-4-{[(1R, 4S, 5R, 8S, 9R, 10S, 12R, 13R)-1, 5, 9-trimethyl-11, 14, 15, 16-tetraoxatetracyclo[10.3.1.0, .0, ]hexadecan-10-yl]oxy}butanoic acid
Smiles :
C[C@@]12CC[C@H]3[C@H](C)CC[C@H]4[C@@H](C)[C@H](OC(=O)CCC(O)=O)O[C@H](O1)[C@]43OO2
InChiKey:
FIHJKUPKCHIPAT-AHIGJZGOSA-N
InChi :
InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).|Product information|CAS Number: 88495-63-0|Molecular Weight: 384.42|Formula: C19H28O8|Chemical Name: 4-oxo-4-{[(1R, 4S, 5R, 8S, 9R, 10S, 12R, 13R)-1, 5, 9-trimethyl-11, 14, 15, 16-tetraoxatetracyclo[10.3.1.0, .0, ]hexadecan-10-yl]oxy}butanoic acid|Smiles: C[C@@]12CC[C@H]3[C@H](C)CC[C@H]4[C@@H](C)[C@H](OC(=O)CCC(O)=O)O[C@H](O1)[C@]43OO2|InChiKey: FIHJKUPKCHIPAT-AHIGJZGOSA-N|InChi: InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.{{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} medchemexpress|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} Biological Activity|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} Data Sheet|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} custom synthesis|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} Cancer} 33 mg/mL (216.{{Dimethyl sulfoxide} web|{Dimethyl sulfoxide} Neuronal Signaling|{Dimethyl sulfoxide} Purity & Documentation|{Dimethyl sulfoxide} In Vivo|{Dimethyl sulfoxide} supplier|{Dimethyl sulfoxide} Autophagy} 77 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32644545 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1). Artesunate treatment for 24 h causes a significant increase in the levels of reactive oxygen species (ROS) in a dose-dependent manner in both cell lines. Moreover, Western blotting shows that the levels ofγ-H2AX are significantly elevated when cancer cells are treated with Artesunate in the higher dose range for 24 h. Artesunate also shows a time-dependent effect on the level of RAD51 in A2780 and HO8910 cells. In two types of non-malignant cells, normal human fibroblasts and immortalized epithelial cells, FTE-187, the level of RAD51 is not altered by Artesunate. In A2780 cells, the level of RAD51 mRNA is indeed decreased by the addition of Artesunate, in a dose-dependent manner. Correspondingly, the promoter activity of RAD51 is significantly inhibited by Artesunate. In contrast, the RAD51 mRNA level in H8910 cells is not affected by Artesunate.|In Vivo:|Tumor growth is significantly reduced in the group receiving combined treatment of Artesunate and cisplatin (PReferences:|Ilamathi M, et al. Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma. Curr Top Med Chem. 2016;16(22):2453-63.Lisewski AM, et al. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 2014 Aug 14;158(4):916-928.Products are for research use only. Not for human use.|
