Product Name :
Pyridostatin TFA
Description:
Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin TFA promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin TFA targets the proto-oncogene Src. Pyridostatin TFA reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.
CAS:
1472611-44-1
Molecular Weight:
710.66
Formula:
C33H33F3N8O7
Chemical Name:
4-(2-aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide; trifluoroacetic acid
Smiles :
NCCOC1C=C(N=C(C=1)C(=O)NC1=CC(OCCN)=C2C=CC=CC2=N1)C(=O)NC1=CC(OCCN)=C2C=CC=CC2=N1.OC(=O)C(F)(F)F
InChiKey:
SLFYRKZWSPFGQZ-UHFFFAOYSA-N
InChi :
InChI=1S/C31H32N8O5.C2HF3O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;3-2(4,5)1(6)7/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);(H,6,7)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin TFA promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin TFA targets the proto-oncogene Src. Pyridostatin TFA reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.|Product information|CAS Number: 1472611-44-1|Molecular Weight: 710.66|Formula: C33H33F3N8O7|Chemical Name: 4-(2-aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide; trifluoroacetic acid|Smiles: NCCOC1C=C(N=C(C=1)C(=O)NC1=CC(OCCN)=C2C=CC=CC2=N1)C(=O)NC1=CC(OCCN)=C2C=CC=CC2=N1.OC(=O)C(F)(F)F|InChiKey: SLFYRKZWSPFGQZ-UHFFFAOYSA-N|InChi: InChI=1S/C31H32N8O5.C2HF3O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;3-2(4,5)1(6)7/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);(H,6,7)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Quercetin} web|{Quercetin} Immunology/Inflammation|{Quercetin} Protocol|{Quercetin} Purity|{Quercetin} supplier|{Quercetin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Bumetanide} site|{Bumetanide} Membrane Transporter/Ion Channel|{Bumetanide} Protocol|{Bumetanide} Purity|{Bumetanide} supplier|{Bumetanide} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31826669 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin TFA is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin TFA causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin TFA induces the formation of DNA DSBs. Remarkably, Pyridostatin TFA (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.|Products are for research use only. Not for human use.|
