Product Name :
LAG-3 (human) monoclonal antibody (17B4)
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Stable for at least 6 months after receipt when stored as recommended.
Description:
The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses. Western blot analysis of LAG-3 mAb (17B4) : Lane 1: MW marker, Lane 2: LAG-3 (human):Fc (human), (recombinant) . Western blot analysis of LAG-3 mAb (17B4) : Lane 1: MW marker, Lane 2: LAG-3 (human):Fc (human), (recombinant) .
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| Alternative Name Lymphocyte activation gene-3, FDC protein, CD223 | Application ICC, IHC, IP, WB | Clone 17B4 | Formulation Liquid.{{2873460-70-7} site|{2873460-70-7} Purity & Documentation|{2873460-70-7} In stock|{2873460-70-7} supplier} In PBS containing 10% glycerol and 0.{{950769-58-1} MedChemExpress|{950769-58-1} Technical Information|{950769-58-1} Data Sheet|{950769-58-1} custom synthesis} 02% sodium azide.PMID:27891836 | Host Mouse | Immunogen Synthetic peptide corresponding to 30 aa (GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY) from the first N-terminal D1 domain of human LAG-3 (lymphocyte activation gene-3). | Isotype IgG1 | Recommendation Dilutions/Conditions Immunohistochemistry (frozen sections, 1:150)Western Blot (5µg/ml)Immunoprecipitation (10µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from hybridoma tissue culture supernatant. | Species Reactivity Human | Specificity Recognizes the 30 aa extra-loop of the first N-terminal D1 domain of LAG-3. | UniProt ID P18627 | Unit of Measure (UM) µg
