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MEKK1 polyclonal antibody
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MEKKs (Mitogen activated protein kinase kinase kinases) are serine-threonine kinases that act as the first tier of cellular MAP kinase pathways by activation of MAP/ERK kinases, or MEKs. Many enzymes with MEKK activity have been identified, including MEKK1-4, Raf, MLK3, TAK, and DLK. MEKKs generally display little similarity outside of their catalytic kinase domains. MEKK1-4 are nearly 50% identical within their catalytic domains, and are known to regulate Erk, Jnk, and p38 MAP kinase pathways. MEKK2 and MEKK3 bind MEK5 via conserved PB1 domains, leading to downstream activation of Erk5. Figure 1. Western Blot analysis using MEKK1, pAb . Figure 1. Western Blot analysis using MEKK1, pAb .
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| Alternative Name MAP3K1, MEK kinase 1, Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MAPKKK1 | Application ELISA, ICC, IHC (FS), IHC (PS), WB | Application Notes Detects a band of ~26KDa by Western blot. | Formulation Liquid. In PBS, pH 7.4, containing 0.{{154525-25-4} medchemexpress|{154525-25-4} Protocol|{154525-25-4} In Vivo|{154525-25-4} manufacturer} 02% sodium azide and 50% glycerol.{{2438637-61-5} medchemexpress|{2438637-61-5} Protocol|{2438637-61-5} In stock|{2438637-61-5} supplier} | Host Rabbit | Immunogen Recombinant MEKK1 (aa 1307-1509).PMID:30969597 | Positive Control Included. | Recommendation Dilutions/Conditions ELISA (1:100-200)Immunocytochemistry (formalin fixed cells) (1:100-500)Immunohistochemistry (frozen sections) (1:100-500)Immunohistochemistry (paraffin sections) (1:50-200)Western blot (1:100-400)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Human | UniProt ID Q13233 | Unit of Measure (UM) µg
