Proinsulin ELISA kit

Description:
Ultra-sensitive Proinsulin ELISA kit enabling detection of proinsulin in human serum and plasma samples in just 3 hours. Ultra-sensitive measurement of proinsulin, detecting as little as 0.17 pM Negligible cross reactivity with insulin High throughput format with results in 3 hours for up to 40 samples in duplicate Fully quantitative results that surpass semi-quantitative Western blot analysis The Proinsulin ELISA kit is a colorimetric immunometric immunoassay kit with results in 3 hours. Type 2 diabetes mellitus is the most common serious metabolic condition in the world, and results from a subnormal response of tissues to insulin (insulin resistance) and a failure of the insulin-secreting beta cells to compensate. Insulin is required for glucose homeostasis and an important precursor protein to insulin is proinsulin. Proinsulin is composed of the A and B subunits of insulin and is connected by the C-peptide region. This 10.5 kDa protein, which contains 110 amino acids, is synthesized as a single chain that contains a 24 amino acid signal sequence and an 86 amino acid proinsulin propeptide. Proinsulin is processed in the endoplasmic reticulum of pancreatic β-cells and is converted within immature secretory granules into insulin and C-peptide.{{83730-53-4} web|{83730-53-4} Protocol|{83730-53-4} In stock|{83730-53-4} supplier} While mature insulin is required for glucose homeostasis and C-peptide is associated with renal function, proinsulin has low metabolic activity. However, it is biologically active and is a regulator of development in prepancreatic embryonic stages. The release of proinsulin is significantly increased in patients with type 2 diabetes as well as in individuals with impaired glucose tolerance (IGT). The levels of proinsulin can also increase with age.{{1399177-37-7} MedChemExpress|{1399177-37-7} Technical Information|{1399177-37-7} References|{1399177-37-7} custom synthesis} Proinsulin ELISA kit Standard curve Proinsulin ELISA kit Kit box image Proinsulin ELISA kit Standard curve Proinsulin ELISA kit Kit box image