Product Name :
CGP 20712 A
Description:
CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.
CAS:
105737-62-0
Molecular Weight:
590.57
Formula:
C24H29F3N4O8S
Chemical Name:
2-hydroxy-5-2-[(2-hydroxy-3-4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxypropyl)amino]ethoxybenzamide; methanesulfonic acid
Smiles :
CN1C=C(N=C1C1C=CC(=CC=1)OCC(O)CNCCOC1=CC=C(O)C(=C1)C(N)=O)C(F)(F)F.CS(O)(=O)=O
InChiKey:
VFPOVCXWKBYDNF-UHFFFAOYSA-N
InChi :
InChI=1S/C23H25F3N4O5.CH4O3S/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33;1-5(2,3)4/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33);1H3,(H,2,3,4)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.|Product information|CAS Number: 105737-62-0|Molecular Weight: 590.57|Formula: C24H29F3N4O8S|Synonym:|CGP 20712 mesylate|Chemical Name: 2-hydroxy-5-2-[(2-hydroxy-3-4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxypropyl)amino]ethoxybenzamide; methanesulfonic acid|Smiles: CN1C=C(N=C1C1C=CC(=CC=1)OCC(O)CNCCOC1=CC=C(O)C(=C1)C(N)=O)C(F)(F)F.CS(O)(=O)=O|InChiKey: VFPOVCXWKBYDNF-UHFFFAOYSA-N|InChi: InChI=1S/C23H25F3N4O5.CH4O3S/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33;1-5(2,3)4/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33);1H3,(H,2,3,4)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (169.Losartan Epigenetics 33 mM; Need ultrasonic).SGI-1776 Immunology/Inflammation |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33131430 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.|In Vivo:|Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.|References:|Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9.Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43.Grino M, et al. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Endocrinology. 1992 Dec;131(6):2763-8.Products are for research use only. Not for human use.|
