Product Name :
Belvarafenib TFA
Description:
Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
CAS:
2443966-84-3
Molecular Weight:
592.95
Formula:
C25H17ClF4N6O3S
Chemical Name:
4-amino-N-1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-ylthieno[3,2-d]pyrimidine-7-carboxamide; trifluoroacetic acid
Smiles :
CC1C=CC2=C(NC3=CC=CC(Cl)=C3F)N=CC=C2C=1NC(=O)C1=CSC2=C(N)N=CN=C21.OC(=O)C(F)(F)F
InChiKey:
MUFMPRYDZZISSM-UHFFFAOYSA-N
InChi :
InChI=1S/C23H16ClFN6OS.C2HF3O2/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26;3-2(4,5)1(6)7/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29);(H,6,7)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.|Product information|CAS Number: 2443966-84-3|Molecular Weight: 592.95|Formula: C25H17ClF4N6O3S|Chemical Name: 4-amino-N-1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-ylthieno[3,2-d]pyrimidine-7-carboxamide; trifluoroacetic acid|Smiles: CC1C=CC2=C(NC3=CC=CC(Cl)=C3F)N=CC=C2C=1NC(=O)C1=CSC2=C(N)N=CN=C21.Thioridazine In Vitro OC(=O)C(F)(F)F|InChiKey: MUFMPRYDZZISSM-UHFFFAOYSA-N|InChi: InChI=1S/C23H16ClFN6OS.Rebaudioside M Purity & Documentation C2HF3O2/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26;3-2(4,5)1(6)7/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29);(H,6,7)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32770252 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively.|Products are for research use only. Not for human use.|
