Product Name :
ASP5878
Description:
ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4, with IC50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity.
CAS:
1453208-66-6
Molecular Weight:
407.37
Formula:
C18H19F2N5O4
Chemical Name:
2-[4-(5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-ylamino)-1H-pyrazol-1-yl]ethan-1-ol
Smiles :
COC1C=C(OC)C(F)=C(COC2C=NC(NC3C=NN(CCO)C=3)=NC=2)C=1F
InChiKey:
VDZZYOJYLLNBTD-UHFFFAOYSA-N
InChi :
InChI=1S/C18H19F2N5O4/c1-27-14-5-15(28-2)17(20)13(16(14)19)10-29-12-7-21-18(22-8-12)24-11-6-23-25(9-11)3-4-26/h5-9,26H,3-4,10H2,1-2H3,(H,21,22,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4, with IC50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity.|Product information|CAS Number: 1453208-66-6|Molecular Weight: 407.37|Formula: C18H19F2N5O4|Chemical Name: 2-[4-(5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-ylamino)-1H-pyrazol-1-yl]ethan-1-ol|Smiles: COC1C=C(OC)C(F)=C(COC2C=NC(NC3C=NN(CCO)C=3)=NC=2)C=1F|InChiKey: VDZZYOJYLLNBTD-UHFFFAOYSA-N|InChi: InChI=1S/C18H19F2N5O4/c1-27-14-5-15(28-2)17(20)13(16(14)19)10-29-12-7-21-18(22-8-12)24-11-6-23-25(9-11)3-4-26/h5-9,26H,3-4,10H2,1-2H3,(H,21,22,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 250 mg/mL (613.69 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.TBB Stem Cell/Wnt |Shelf Life: ≥12 months if stored properly.Flubendazole Autophagy |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32697111 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ASP5878 shows potent antiproliferative activity in most human HCC cell lines. ASP5878 inhibits FGFR4 phosphorylation in a concentration-dependent manner. ASP5878 treatment results in the suppression of phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation.|In Vivo:|ASP5878 (3 mg/kg, orally, once daily) shows antitumor activity in a Hep3B2.1-7 subcutaneous xenograft and HCC orthotopic xenograft mouse model. ASP5878 induces shrinkage of FGF19-expressing HCC xenograft model.|Products are for research use only. Not for human use.|
