Product Name :
Rabbit anti-ITGA7 Polyclonal Antibody(N-term)
Synonym :
Integrin alpha-7; Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form; ITGA7
Host :
Rabbit
Species Reactivity:
Human
Specificity :
This ITGA7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 247-279 amino acids from the N-terminal region of human ITGA7.
Predicted Reactivity:
Applications :
IF~~1:25IHC-P~~1:25FC~~1:25WB~~1:4000
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Crown Antibodies
Background :
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
UniProt :
Q13683
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Purified Rabbit Polyclonal Antibody (Pab) |Synonym Integrin alpha-7; Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form; ITGA7 |Host Rabbit |Specificity This ITGA7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 247-279 amino acids from the N-terminal region of human ITGA7. |Species Reactivity Human |Applications IF~~1:25IHC-P~~1:25FC~~1:25WB~~1:4000 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Research areas Crown Antibodies |Target |Background Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. |Cellular localization Membrane; Single-pass type I membrane protein |UniProt Q13683 |References |References Leung E.,et al.Biochem. Biophys. Res. Commun. 243:317-325(1998).Hayashi Y.K.,et al.Nat. Genet. 19:94-97(1998).Vizirianakis I.S.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.Vignier N.,et al.Biochem. Biophys. Res. Commun. 260:357-364(1999).Clark H.F.,et al.Genome Res. 13:2265-2270(2003). |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-ITGA7 Polyclonal Antibody(N-term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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