390/molecules26195757 Academic Editor: Raffaele Pezzani Received: 21 August 2021 Accepted: 16 September 2021 Published: 23 September10 9Department of Medicinal Chemist and Pharmacognosy, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia; [email protected] Division of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo 11371, Egypt Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia; [email protected] (S.A.A.M.); [email protected] (M.S.M.S.) Division of 5-HT3 Receptor Agonist MedChemExpress Biochemistry, Faculty of Medicine, Al-Azhar University, Assiut 71524, Egypt Division of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, JUST, Irbid 22110, Jordan Hospital of Police Academy, Nasr city, Cairo 11765, Egypt; mohamedshawky1974@yahoo Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt; [email protected] Department of Pharmaceutics, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia; [email protected] Division of Clinical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Abdia, Makkah 21955, Saudi Arabia; [email protected] (S.Y.E.); [email protected] (M.Z.E.-R.) Division of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; [email protected] Correspondence: [email protected] (H.A.M.); [email protected] (H.M.E.); [email protected] (R.A.K.); Tel.: +00966566176074 (H.A.M.)Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This short article is an open access short article distributed under the terms and conditions of your Creative Commons Attribution (CC BY) license ( creativecommons.org/licenses/by/ four.0/).Abstract: Sage, Salvia officinalis L., is utilised worldwide as an aromatic herb for culinary purposes too as a traditional medicinal agent for a variety of ailments. Existing investigations exhibited the effects of extended dryings with the herb on the yields, composition, oil quality, and hepatoprotective also as anti-cancer biological activities of your hydrodistillation-obtained crucial oils from the aerial parts in the plant. The necessary oils’ yields, compositions, and biological activities levels of your fresh and differently timed and room-temperature dried herbs differed considerably. The lowest yields of the important oil have been obtained in the fresh herbs (FH, 631 mg, 0.16 ), whilst the highest yield was obtained from the two-week dried herbs (2WDH, 1102 mg, 0.28 ). A notable lower in monoterpenes, with increment in the sesquiterpene constituents, was observed for the FH-based crucial oil as in comparison with all of the other batches of your essential oils obtained from the differenttimed dried herbs. Additionally, characteristic chemotypic constituents of sage, i.e., -pinene, camphene, -pinene, myrcene, 1, 8-cineole, -thujone, and camphor, were present in substantially larger proportions in each of the dried herbs’ vital oils as when compared with the FH-based necessary oil. The in vivo hepatoprotective activity demonstrated significant reductions in the levels of AST, ALT, and ALP, as well as a significant boost inside the total protein (p 0.05) contents level, as in comparison with the S1PR3 Formulation acetaminophen (AAP) administered experimental group of rats. A substantial reduction (p 0.05) inside the ALT level was demonstrated by the 4W
