Product Name :
U0126
Description:
U0126 is a potent and selective non-competitive inhibitor of MAP kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively).
CAS:
109511-58-2
Molecular Weight:
380.49
Formula:
C18H16N6S2
Chemical Name:
bis({amino[(2-aminophenyl)sulfanyl]methylidene})butanedinitrile
Smiles :
NC1=CC=CC=C1SC(N)=C(C#N)C(C#N)=C(N)SC1=CC=CC=C1N
InChiKey:
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
InChi :
InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
U0126 is a potent and selective non-competitive inhibitor of MAP kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively).|Product information|CAS Number: 109511-58-2|Molecular Weight: 380.49|Formula: C18H16N6S2|Synonym:|U 0126|Related CAS Number:|1173097-76-1 (U0126-EtOH)|Chemical Name: bis({amino[(2-aminophenyl)sulfanyl]methylidene})butanedinitrile|Smiles: NC1=CC=CC=C1SC(N)=C(C#N)C(C#N)=C(N)SC1=CC=CC=C1N|InChiKey: DVEXZJFMOKTQEZ-JYFOCSDGSA-N|InChi: InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 85 mg/mLwarmed(199.26 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|U0126-EtOH functionally antagonizes AP- 1 transcriptional activity and blocks the production of a variety of cytokines and metalloproteinases involved in the inflammatory response. U0126-EtOH inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs without effect on IL-2-induced proliferation by down-regulating IL-2 mRNA levels.{{Belimumab} MedChemExpress|{Belimumab} CD20|{Belimumab} Biological Activity|{Belimumab} In Vivo|{Belimumab} manufacturer|{Belimumab} Cancer} A recent study shows that U0126-EtOH antagonizes resveratrol-induced apoptosis in castration-resistant human prostate cancer C4-2 cells, inhibits mitochondrial function and shifts cells to aerobic glycolysis independently of MEK.{{Danavorexton} web|{Danavorexton} Orexin Receptor (OX Receptor)|{Danavorexton} Epigenetics|{Danavorexton} Technical Information|{Danavorexton} Purity|{Danavorexton} supplier} |In Vivo:|U0126-EtOH, as the inhibitor of intracellular Raf/MEK/ERK signaling pathway, demonstrates antiviral activity by suppressing propagation of the 2009 pandemic IV H1N1 variant and highly pathogenic avian influenza viruses (HPAIV) in vivo in the mouse lung by inhibiting.PMID:23991096 U0126-EtOH shows the potential neuroprotective effect and improving spatial learning in Morris water maze (MWM) by activating peroxisome proliferator-activated receptor gamma coactivator-1a, nuclear respiratory factor 1, and mitochondrial transcription factor A in Aβ-injected rats.|References:|Freeman MR, et al. Cancer Biol Ther. 2011, 12(11), 966-977.DeSilva DR, et al. J Immunol. 1998, 160(9), 4175-4181.Duncia JV, et al. Bioorg Med Chem Lett. 1998, 8(20), 2839-2844.Products are for research use only. Not for human use.|
