Product Name :
Autotaxin-IN-1
Description:
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.
CAS:
1619971-30-0
Molecular Weight:
405.45
Formula:
C21H23N7O2
Chemical Name:
1-{2-[(2,3-dihydro-1H-inden-2-yl)amino]-5H,6H,7H-pyrrolo[3,4-d]pyrimidin-6-yl}-2-[2-(2H-1,2,3-triazol-4-yl)ethoxy]ethan-1-one
Smiles :
O=C(COCCC1C=NNN=1)N1CC2=NC(NC3CC4=CC=CC=C4C3)=NC=C2C1
InChiKey:
ILOFWCAZDNILKY-UHFFFAOYSA-N
InChi :
InChI=1S/C21H23N7O2/c29-20(13-30-6-5-17-10-23-27-26-17)28-11-16-9-22-21(25-19(16)12-28)24-18-7-14-3-1-2-4-15(14)8-18/h1-4,9-10,18H,5-8,11-13H2,(H,22,24,25)(H,23,26,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.|Product information|CAS Number: 1619971-30-0|Molecular Weight: 405.45|Formula: C21H23N7O2|Chemical Name: 1-{2-[(2,3-dihydro-1H-inden-2-yl)amino]-5H,6H,7H-pyrrolo[3,4-d]pyrimidin-6-yl}-2-[2-(2H-1,2,3-triazol-4-yl)ethoxy]ethan-1-one|Smiles: O=C(COCCC1C=NNN=1)N1CC2=NC(NC3CC4=CC=CC=C4C3)=NC=C2C1|InChiKey: ILOFWCAZDNILKY-UHFFFAOYSA-N|InChi: InChI=1S/C21H23N7O2/c29-20(13-30-6-5-17-10-23-27-26-17)28-11-16-9-22-21(25-19(16)12-28)24-18-7-14-3-1-2-4-15(14)8-18/h1-4,9-10,18H,5-8,11-13H2,(H,22,24,25)(H,23,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Modakafusp alfa} medchemexpress|{Modakafusp alfa} Immunology/Inflammation|{Modakafusp alfa} Protocol|{Modakafusp alfa} In stock|{Modakafusp alfa} manufacturer|{Modakafusp alfa} Cancer} |Shelf Life: ≥12 months if stored properly.{{Fludarabine} MedChemExpress|{Fludarabine} STAT|{Fludarabine} Immunology/Inflammation|{Fludarabine} Biological Activity|{Fludarabine} Description|{Fludarabine} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32962555 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours. Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM•h.|Products are for research use only. Not for human use.|
