Product Name :
SAG
Sequence:
Purity:
≥95% (HPLC)
Molecular Weight:
490.1
Solubility :
Soluble in DMSO (10mg/ml), sparingly soluble in water (acidification with HCl increases water solubility).
Appearance:
White to off-white solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended. Stock solutions in DMSO are stable for at least 1 month when stored at -20°C.
Description:
Smoothened agonist Potent Smoothened (Smo) receptor agonistBinds directly to Smo and antagonizes CyclopamineEnhancer of neuronal differentiation of iPSCs into dopaminergic neurons Smoothened (Smo) is a transmembrane receptor that relays the Hedgehog (Hh) signal and plays an essential role during embryonic development and tumorigenesis. SAG is a potent cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG was shown to induce Hedgehog pathway activation independently of the Hh binding receptor Patched (Ptch) (EC50= ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteract inhibition of Smo by Cyclopamine . Smo is reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
CAS :
912545-86-9
Solubility:
Soluble in DMSO (10mg/ml), sparingly soluble in water (acidification with HCl increases water solubility).866924-39-2 Purity & Documentation
Formula:
C28H28ClN3OS
Additional Information :
| Alternative Name 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide | Appearance White to off-white solid.1609392-27-9 Description | CAS 912545-86-9 | Couple Target Smoothened | Couple Type Activator, Ligand | Formula C28H28ClN3OS | Identity Identity determined by MS and NMR.PMID:20301593 | MW 490.1 | Purity ≥95% (HPLC) | Solubility Soluble in DMSO (10mg/ml), sparingly soluble in water (acidification with HCl increases water solubility). | Unit of Measure (UM) mg
