Product Name: GOLPH3 (905CT9.1.1) Monoclonal Antibody
Applications: WB
Reactivity: Human
Conjugation: Unconjugated
Host: Mouse
Sourcr: Purified His-tagged GOLPH3 protein was used to produced this monoclonal antibody.
Clonality: Monoclonal
CAS NO: 14367-47-6
Product: Metrifonate
Isotype: IgG1
Concentration:
Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Synonyms: GOPP1; GPP34; MIDAS; Vps74; Golgi phosphoprotein 3; Coat protein GPP34; Mitochondrial DNA absence factor; GOLPH3
Background: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19328065?dopt=Abstract
