pathways with the Transcription 
Factors in the Preeclamptic Placenta Gene LEP FLT1 HTRA1 QPCT SPAG4 INHA PAPPA2 SIGLEC6 ENG INHBA BCL6 SLC26A6 GREM2 EBI3 HTRA4 FSTL3 BHLHE40 EntrezGene ID 3952 2321 5654 25797 6676 3623 60676 946 2022 3624 604 65010 64388 10148 203100 10272 8553 GSE4707 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 GSE24129 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 GSE10588 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 GSE25906 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 GSE14722 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 GSE30186 1 1 1 1 – The table shows some of the consistently up-regulated genes in the six preeclamptic placenta microarray studies analyzed. The microarrays are identified by their GEO data set accession number. Indicates modified in the microarrays, Indicates not-modified. Complete consensus list of up-regulated genes in the preeclamptic placenta is provided as . In addition, an alternative regulatory module of two elements was found present 21505263 in the promoter of six out of the seven TFs consistently up-regulated in the preeclamptic placenta. In the case of the consistently down-regulated TFs we found one highly significant model composed of six elements corresponding to TFBS for E2FF, RXRF, KLFS and ZF02. This module was present in the promoter of three out of four genes. Gene CLDN1 ABAT MFF GCLM F13A1 SOD1 APLN ABCG2 GOT1 SLC23A2 OLFML3 LEPREL1 BHLHE41 FAM101B NR2F1 EntrezGene ID 9076 18 56947 2730 2162 6647 8862 9429 2805 9962 56944 55214 79365 359845 7025 GSE4707 1 1 1 1 1 – GSE24129 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 GSE10588 1 1 1 1 1 1 1 1 1 1 1 1 1 GSE25906 1 1 1 1 1 1 1 1 1 1 1 1 GSE14722 1 1 1 1 1 1 1 1 1 1 1 1 GSE30186 1 1 1 1 1 1 – The table shows some of the consistently down-regulated genes in the six preeclamptic placenta microarray studies analyzed. The microarrays are identified by their GEO data set accession number. Indicates modified in the microarrays, Indicates not-modified. Complete consensus list of down-regulated genes in the preeclamptic placenta is provided as 4 Transcription Factors in the Preeclamptic Placenta Database GO:0023052 Functional annotation Signaling N6 of genes 36 Genes HTRA1, HEXB, CEBPA, DDR1, LYN, CYP26A1, ENG, APLP2, EBI3, KIT, HLPDA, SYDE1, RASEF, PREX1, BAD, VDR, INSIG1, FLT1, LHB, FSTL3, SCARB1, LIMD1, MIF, BHLHE40, SIGLEC6, TREM1, LEP, GREM2, ERRFI1, NRIP1, INHBA, CORO2A, ERO1L, INHA, T0070907 SH3BP5, NEK111 HTRA1, HEXB, DDR1, LYN, CYP26A1, ENG, APLP2, BCL6, KIT, GAPDH, EZR, BAD, VDR, KIF2A, LHB, HTRA4, SCARB1, BHLHE40, PAPPA2, TREM1, LEP, INHBA, INHA, HK2, PROCR CEBPA, LYN, KIT, FSTL3, LEP, 11325787 INHBA, INHA7 tHTRA1, CEBPA, DDR1, LYN, CYP26A1, ENG, APLP2, EBI3, KIT, SYDE1, RASEF, PREX1, BAD, VDR, INSIG1, FLT1, LHB, FSTL3, SCARB1, LIMD1, MIF, TREM1, LEP, GREM2, ERRFI1, NRIP1, INHBA, CORO2A, ERO1L, INHA, SH3BP5, NEK111 BAD, INHBA, INHA1 GPX3, HEXB, DDR1, APLP2, KIT, IGSF8, VDR, FLT1, LHB, LEP, NRIP1, INHBA, SPAG4, INHA, HK2 EBI3, INHBA, INHA2 CEBPA, DDR1, LYN, ENG, EBI3, KIT, HLPDA, IGSF8, BAD, VDR, INSIG1, FLT1, SCARB1, MIF, INHBA, INHA P-Value 1.73E-06 GO:0065008 Regulation of biological quality 25 3.42E-06 GO:0030099 GO:0007165 Myeloid cell differentiation signal transduction 7 32 7.47E-06 1.72E-05 GO:0045577 GO:0022414 GO:0045072 GO:0008283 B cell differentiation Reproductive process Interferon-gamma biosynthesis Cell proliferation 3 15 3 16 1.81E-05 2.74E-05 2.98E-05 5.99E-05 doi:10.1371/journal.pone.0065498.t004 Transcription Factors Interactome We used the STRING database to search for known interactions among the TFs identified
