Product Name: HINT1 (1500CT836.13.93) Monoclonal Antibody
Applications: IHC-P, IF
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Mouse
Sourcr: This HINT1 antibody is generated from a mouse immunized with a recombinant protein of human HINT1.
Clonality: Monoclonal
CAS NO: 32222-06-3
Dabrafenib (Mesylate)
Isotype: IgG1 κ
Concentration:
Purification:
Storage: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Synonyms: HINT; NMAN; PKCI-1; PRKCNH1; Histidine triad nucleotide-binding protein 1; Adenosine 5-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; HINT1; PKCI1
Background: Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5monophosphoramidate (AMP-NH2), adenosine 5monophosphomorpholidate (AMP-morpholidate) and guanosine 5monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5-O-phosphorothioate and guanosine 5-O-phosphorothioate to the corresponding nucleoside 5-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22892241?dopt=Abstract
